系所：基础兽医学系
职称：副教授
电子邮箱：jiaohanwei@swu.edu.cn
讲授课程：《动物生理学》、《动物生理学实验》、《动物医学外文文献阅读》
个人简介：
焦寒伟，男，重庆彭水人，博士，副教授。国家“三区”科技人才，重庆市科技特派员。主持国家自然科学基金青年基金项目、重庆市自然科学基金面上项目、动物疫病防控全国重点实验室开放课题、中央高校基本科研业务费面上项目和能力提升项目、研究中心和企业横向项目等十余项；受聘《Frontiers in Cellular and Infection Microbiology》期刊评审编辑，并主持前沿专刊；担任《Veterinary Sciences》评审委员会成员；担任《Zoonoses》期刊首届和第二届青年编委/《Animals and Zoonoses》青年编委；受聘国研评审中心的评阅专家；担任重庆市巴南区石龙镇创业园指导专家；主持“动物布病、结核病和支原体病研究国际研讨会”布病专场，并做主题报告；作为第一发明人申报国家发明专利6项；以第一作者或通讯作者在Transboundary and Emerging Diseases等国内外著名期刊公开发表学术论文近50篇；担任Virulence、Veterinary Research等多个SCI期刊的审稿人。
教育经历：
2006.9-2010.7 本科 海南大学 动物科学专业（动物医学）
2010.9-2012.7 硕博连读(硕士) 海南大学 野生动植物保护与利用专业
2012.9-2016.12 硕博连读(博士) 海南大学 生物化学与分子生物学
工作经历：
2017.7－2020.7 西南大学动物科学学院；
2020.7－至今 西南大学动物医学院。
研究领域：
主要从事人兽共患病-布鲁氏菌致病机制和新型疫苗开发、功能性益生菌和微生态制剂开发。
主要纵向科研项目：
1.国家自然科学基金青年基金项目，布鲁氏菌wbkc影响RAW264.7细胞自噬的分子机制研究，2019/01-2022/01，主持；
2.重庆市自然科学基金面上项目，基因IV型猪戊型肝炎病毒ORF3蛋白介导HepG2核黄素代谢通路circRNA的鉴定及调控机理研究，2022/08~2024/07, 主持；
3.动物疫病防控全国重点实验室开放课题，布鲁氏菌外膜蛋白Omp25通过lncRNA/miR-149-3p/Ptpn5轴调控巨噬细胞自噬的机制研究， 2022/06~2024/06, 主持；
4.中央高校基本科研业务费-能力提升项目，circRNA靶向miR-146a-5p/Dusp16轴调控布氏杆菌外膜蛋白Omp25介导巨噬细胞自噬的机制研究，2022/01~2024/12, 主持；
5.中央高校基本科研业务费项目，联合蛋白质组和全转录组测序分析猪戊型肝炎病毒ORF3蛋白影响HepG2细胞内源性lncRNA-miRNA-mRNA-蛋白的分子调控机制，2020/1-2021/12，主持。
主要横向科研项目：
1.研究中心横向项目，一株猪源功能性益生菌-乳酸菌的分离鉴定及其益生特性研究，项目经费300.00万元，2026/01-2026/12, 主持。
部分代表论文（第一作者或通讯作者）：
1.Chi Meng, Fengyuan Jiao, Gengxu Zhou, Lingjie Wang, Shengping Wu, Cailiang Fan, Jixiang Li, Liting Cao, Zuoyong Zhou, Yuefeng Chu, Hanwei Jiao*. Selective Autophagy Mediated by Protein Ubiquitination in Major Prevalent Zoonoses. Transboundary and Emerging Diseases, 2025, 2025(1):1-14.
2.Hanwei Jiao*, Gengxu Zhou, Shengping Wu, Chi Meng, Lingjie Wang, Cailiang Fan, Jixiang Li, Yuefeng Chu*. Brucella Immune Escape: TLR Subversion, Antigen Presentation Destruction and T Cell Disorder. Cells, 2025, 14(22):1809.
3.Jing Tu, Shengping Wu, Lingjie Wang, Chi Meng, Gengxu Zhou, Jianhua Guo, Jixiang Li, Liting Cao, Zhenhui song, Hanwei Jiao*. Identification of Riboflavin Metabolism Pathway in HepG2 Cells Expressing Genotype IV Swine Hepatitis E Virus ORF3 Protein. Veterinary Sciences, 2025, 12(9):912.
4.Hanwei Jiao*, Shengping Wu, Lingjie Wang, Chi Meng, Gengxu Zhou, Jianhua Guo, Liting Cao, Yu Zhao, Zhenhui Song, Jake Wen*. Bioinformatics Analysis of the Key lncRNAs of the Viral Response Pathway in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3. Microorganisms, 2025, 13(9):2086.
5.Hanwei Jiao*, Chi Meng, Fengyuan Jiao, Gengxu Zhou, Lingjie Wang, Shengping Wu, Cailiang Fan, Jixiang Li, Liting Cao, Yu Zhao, Yichen Luo*. Descriptive Comparative Transcriptomic Analysis of Genotype IV SHEV ORF3-Expressing HepG2 Cells. Microorganisms, 2025, 13(2):412.
6.Hanwei Jiao, Chi Meng, Lingjie Wang, Shengping Wu, Gengxu Zhou, Yubo Qi, Jianhua Guo, Yu Zhao, Zuoyong Zhou, Ling Gan, Jake Wen*. Multiple Transcriptome Analyses Reveal the Selected lncRNA-mRNA and circRNA-mRNA Networks in HepG2 Cells Expressing Genotype 4 Swine Hepatitis E Virus ORF3. Veterinary Sciences, 2025, 12(12):1151.
7.Hanwei Jiao, Lingjie Wang, Chi Meng, Shengping Wu, Yubo Qi, Jianhua Guo, Jixiang Li, Liting Cao, Yu Zhao, Jake J Wen *, Fengyang Wang*. Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus. Microorganisms, 2025, 13(12):2654.
8.Qin Y, Zhou G, Jiao F, Cheng C, Meng C, Wang L, Wu S, Fan C, Li J, Zhou B, Chu Y, Jiao H*. Brucella mediates autophagy, inflammation, and apoptosis to escape host killing. Front Cell Infect Microbiol, 2024, 14:1408407.
9.Jiao F, Zhao Y, Zhou G, Meng C, Wang L, Wu S, Li J, Cao L, Zhou B, Luo Y, Jiao H*. Multiple Functions of Hepatitis E Virus ORF3. Microorganisms, 2024, 12(7):1405.
10.Guo X, Zeng H, Li M, Xiao Y, Gu G, Song Z, Shuai X, Guo J, Huang Q, Zhou B, Chu Y, Jiao H*. The mechanism of chronic intracellular infection with Brucella spp. Front Cell Infect Microbiol, 2023, 13:1129172.
11.Xiao Y, Li M, Guo X, Zeng H, Shuai X, Guo J, Huang Q, Chu Y, Zhou B, Wen J, Liu J, Jiao H*. Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells. Int J Mol Sci, 2022, 23(21):13417.
12.Xiong X, Li B, Zhou Z, Gu G, Li M, Liu J, Jiao H*. The VirB System Plays a Crucial Role in Brucella Intracellular Infection. Int J Mol Sci, 2021, 22(24):13637.
13.Jiao H*, Shuai X, Luo Y, Zhou Z, Zhao Y, Li B, Gu G, Li W, Li M, Zeng H, Guo X, Xiao Y, Song Z, Gan L, Huang Q. Deep Insight Into Long Non-coding RNA and mRNA Transcriptome Profiling in HepG2 Cells Expressing Genotype IV Swine Hepatitis E Virus ORF3. Front Vet Sci, 2021, 8:625609.
14.Jiao H*, Zhou Z, Li B, Xiao Y, Li M, Zeng H, Guo X, Gu G. The Mechanism of Facultative Intracellular Parasitism of Brucella. Int J Mol Sci, 2021, 22(7):3673.
15.Jiao H, Zhao Y, Zhou Z, Li W, Li B, Gu G, Luo Y, Shuai X, Fan C, Wu L, Chen J, Huang Q, Wang F, Liu J*. Identifying Circular RNAs in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3 Via Whole Genome Sequencing. Cell Transplant, 2021, 30:9636897211055042.
16.Zhou Z, Gu G, Luo Y, Li W, Li B, Zhao Y, Liu J, Shuai X, Wu L, Chen J, Fan C, Huang Q, Han B, Wen J, Jiao H*. Immunological pathways of macrophage response to Brucella ovis infection. Innate Immun, 2020, 26(7):635-648.
17.Jiao H*, Li B, Zheng Z, Zhou Z, Li W, Gu G, Liu J, Luo Y, Shuai X, Zhao Y, Liu Y, Wang Y, Wang X, Hu X, Wu L, Chen J, Huang Q. Transcriptome Landscape of Intracellular Brucella ovis Surviving in RAW264.7 Macrophage Immune System. Inflammation, 2020,43(5):1649-1666.
18.Jiao H*, Luo Y, Zhou Z, Gu G, Li B, Li W, Liu Y, Wang Y, Wang X, Zhao Y, Wu L, Chen J, Shuai X, Huang Q. Integrative Bioinformatics Indentification of the Autophagic Pathway-Associated miRNA-mRNA Networks in RAW264.7 Macrophage Cells Infected with ∆Omp25 Brucella melitensis. Inflammation, 2020, 43(2):532-539.
19.Jiao H*, Zheng Z, Shuai X, Wu L, Chen J, Luo Y, Zhao Y, Wang H, Huang Q. MicroRNA expression profiles from HEK293 cells expressing H5N1 avian influenza virus non-structural protein 1. Innate Immun, 2019, 25(2):110-117.